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Anti-Southern bias in the North has roots in the impact of malaria on Southern communities.

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Northern productivity is hailed as "superior," in contrast to Southern "laziness" during this time period. Thomas Jefferson refers to Southerners as "unsteady" and "indolent," and other local leaders do the same, describing the Southern worker in ways that allude to the symptoms and impact of malaria, which is rampant across the South.