Explosion in global trade due to new technologies also opens up greater exposure to new diseases.
Date: 1900s
The construction of canals and then railroads over the previous 80 years doubles world economic production and creates a local appetite for non-local goods.
Prior to these shifts in the transportation grid, non-local products were rare and most often only enjoyed by the wealthy. New shipping and rail strategies expand access and bring an increase in new disease contact, along with luxuries like oranges in winter.