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The first large-scale clinical trial of a complementary and alternative medicine is launched.

1997

ICM
PHA
RSCH
MED

The trial is launched by the National Institute of Mental Health (NIMH), NIMH's Office of Dietary Supplements (ODS), and the Office of Administrative Management (OAM).

It tests St. John's Wort, an herb, as a treatment for major depression. The results show it has some effects for minor depression, but not for major depression.