The maker of the "Vegetable Universal Pill" is the largest advertiser in U.S. media.
Date: 1849
A congressional committee in 1849 reports that Brandreth, the maker of the pill, is the nation’s largest proprietary advertiser. They claim that the pill removes toxins from the body. Between 1862 and 1863 Brandreth’s average annual gross income will surpass $600,000.