The Pequot community in what is known today as the Connecticut Valley is devastated by smallpox.
Date: 1637
When none of the colonizers become sick, they see the extermination of the Pequot as an act of God. The colonizers turn on the surviving Pequot, including children and elders, killing most of them. They rename the town "New London" and forbid anyone, including the surviving Pequot community members, to refer to the old name.