The largest human trial of Depo-Provera is conducted over eleven years through the Grady Clinic in Atlanta, Georgia on 14,000 women. Fifty percent of the subjects in this experiment come from low-income backgrounds, and are predominantly rural Black and white women.

The trials are conducted on many of these women without their knowledge or consent, which violates Food and Drug Administration (FDA) regulations as the drug has not been approved. Participants are also not told that there are side effects associated with Depo-Provera.

These trials are still rarely linked to the eugenic practices of forced sterilization admitted under state-by-state laws, especially in the U.S. South.