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Magazine cover for "A Study In Scarlet" by A. Conan Doyle. A man in red sits in a chair with his face turned toward a source of light.
Cover of "A Study in Scarlet," the first story to feature Sherlock Holmes.

The Sherlock Holmes mystery fiction series popularizes cocaine.

Date: 1887

DRUG
Cover of "A Study in Scarlet," the first story to feature Sherlock Holmes.

In the books, Holmes uses cocaine to sharpen his deductory skills.